Associate Scientist III, Cardiac Modeling Job at Insitro, South San Francisco, CA

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  • Insitro
  • South San Francisco, CA

Job Description

Insitro seeks an Associate Scientist III to develop and apply iPSC-derived cardiomyocyte models for studying cardiovascular disease genetics and mechanisms. The role combines stem cell biology, cardiac physiology, and experimental assay development to generate datasets supporting machine learning-driven drug discovery.

Responsibilities

  • Generate and maintain iPSC lines, differentiate into cardiomyocytes in 2D format with rigorous quality control
  • Build and characterize isogenic iPSC-CM disease models carrying disease-associated genetic variants
  • Develop and optimize functional assays for cardiovascular disease phenotypes in high-throughput formats
  • Document procedures, maintain technical SOPs, and communicate results with scientific rigor
  • Support target identification by linking cellular phenotypes to human genetic evidence

Requirements

  • Bachelor's or master's degree in biology, biochemistry, or related field
  • At least 2 years of biotech or biopharma industry experience
  • Deep hands-on expertise in iPSC culture and cardiac directed differentiation
  • Experience developing genetic iPSC-CM disease models using patient-derived or CRISPR-edited lines
  • Proficiency with functional assays: contractility, calcium handling, electrophysiology, or imaging
  • Competency in molecular assays including PCR, RT-qPCR, Western Blot, immunofluorescence
  • Background in cardiomyocyte biology or cardiovascular disease preferred

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